Systematic Review of Signs and Symptoms Associated with HSCT-TMA

Our colleagues recently participated in the first systematic literature review and meta-analysis on the signs and symptoms associated with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). The recent open access publication published in Transplantation and Cellular Therapy provides a robust synthesis of currently available evidence. The findings will improve our understanding of HSCT-TMA, a complex and difficult to diagnose condition resulting from allogeneic stem cell transplantation. With an improved understanding of HSCT-TMA, there is the potential for improved diagnostic accuracy and improved outcomes. This study identified additional associations with HSCT-TMA, including increased pulmonary hypertension, respiratory failure and gastrointestinal bleeding. These symptoms might be included for evaluation in future diagnostic criteria and current practice.

Citation: Dandoy C, Tsong W, Sarikonda K, et al. Systematic Review of Signs and Symptoms Associated with Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy. Transplant Cell Ther. 2022 Dec 30;S2666-6367(22)01873-5. doi: 10.1016/j.jtct.2022.12.023. Online ahead of print.